import pandas as pd
df=pd.read_excel('your_file_name.xlsx')
drop_cols=[,,,] #list of columns to get rid of
df.drop(drop_cols,axis='columns')
col_dict={'col-a':'col-x','col-b':'col-y','col-c':'col-z'} #however you want to map you new columns in this example abc are old columns and xyz are new ones
#this line will actually rename your columns with the dictionary
df=df.rename(columns=col_dict)
df.to_csv('new_file_name.csv') #write new file
